Rheumatic fever and carditis are most often preceded by infection with which organism?

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Multiple Choice

Rheumatic fever and carditis are most often preceded by infection with which organism?

Explanation:
Rheumatic fever and carditis are driven by an immune response to a preceding infection with group A Streptococcus, typically from a streptococcal throat infection (strep throat). The immune system makes antibodies against the bacterial M protein, which can cross-react with heart and joint tissues. This molecular mimicry sparks inflammation in the heart (carditis) and joints, along with other features of rheumatic fever. That specific link to group A Streptococcus explains why this organism is the correct antecedent. Other organisms listed—like Staphylococcus aureus, Escherichia coli, or Candida albicans—do not provoke rheumatic fever in this classic, immune-mediated way.

Rheumatic fever and carditis are driven by an immune response to a preceding infection with group A Streptococcus, typically from a streptococcal throat infection (strep throat). The immune system makes antibodies against the bacterial M protein, which can cross-react with heart and joint tissues. This molecular mimicry sparks inflammation in the heart (carditis) and joints, along with other features of rheumatic fever. That specific link to group A Streptococcus explains why this organism is the correct antecedent. Other organisms listed—like Staphylococcus aureus, Escherichia coli, or Candida albicans—do not provoke rheumatic fever in this classic, immune-mediated way.

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